ING1 protein

Riabowol Lab

Welcome to the
Riabowol Lab

Discovering the molecular keystones of aging and cancer through epigenetic research. Explore our groundbreaking work on tumour suppressors, telomere biology, and the genetic mechanisms behind accelerated aging syndromes.

ING1 protein

Investigating Epigenetic Controls in
Cancer and Aging

The Riabowol Laboratory investigates the mechanisms that maintain cellular senescence in normal cells and how these are bypassed during cancerous immortalization. Focusing on telomeres, tumor suppressors, and transcription factors, the lab has identified a novel tumor suppressor, ING1, which plays a crucial role in cellular aging and immortalization. The ING gene family produces over 15 proteins through alternative splicing and promoter usage, featuring PHD domains that bind the H3K4Me3 histone mark, integral to active transcription. This interaction allows the proteins to modulate chromatin structure and gene expression by targeting either histone acetyltransferase (HAT) or histone deacetylase (HDAC) complexes. Research includes developing knockout models to study telomeres' impact on biological aging and the role of ING proteins in cell development and aging.

Karl Riabowol

Dr. Karl Riabowol

Principal Investigator

Dr. Riabowol is a full tenured Professor at the University of Calgary where he heads the Aging and Immortalization Laboratory within the Robson DNA Sciences Centre. Following training at Simon Fraser University, the University of Southern California, University of Arkansas for Medical Sciences and Cold Spring Harbor Laboratory, he held a staff position at Cold Spring Harbor Lab before joining the Cancer Biology Research Group at the University of Calgary in 1991. He served two terms as the Head of the Cancer Biology Group in the University of Calgary's Faculty of Medicine and as Vice Director of the Southern Alberta Cancer Research Institute.

Current Members

Alexander Hill

Alexander Hill

Research Assistant

Yang Yang

Yang Yang

M.D. Ph.D. Research Associate / Lab Manager

Hokan Krowicki

Hokan Krowicki

M.Sc. Graduate Student

Linh Tran

Linh Tran

Undergraduate student

Katayoun Heshmatzad

Katayoun Heshmatzad

Ph.D. Graduate Student

Yuri Romanov

Yuri Romanov

M.Sc. Graduate Student

Mahbod Djamshidi

Mahbod Djamshidi

Ph.D. Graduate Student

Sergey Dadoyan

Sergey Dadoyan

M.Sc. Graduate Student

Mia Brown

Mia Brown

Undergraduate student

Halle Deakin

Halle Deakin

Undergraduate Summer Student

Ryota Tanida

Ryota Tanida

Post-doctoral Fellow

Tom J. (TJ) Bartizal

Tom J. (TJ) Bartizal

Ph.D. Student

Jung Kwon Lee

Jung Kwon Lee

Post-doctoral Fellow

Fatemeh Hashemi

Fatemeh Hashemi

M.Sc. Graduate Student

Harry Peery

Harry Peery

Ph.D. Research Associate

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Contact

Administrative Assistant:

Benedicta Odame-Ankrah

Email: b.odameankrah@ucalgary.ca

Office: 403.220.3029

Phone Number:

Office: 403.220.8695

Lab: 403.220.8696

Address:

Arnie Charbonneau Cancer Institute

3280 Hospital Dr NW

Calgary, AB T2N 4Z6

Office: HMRB374

Lab: HRIC 2A28

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ING1 protein

Riabowol Lab

© 2024 Riabowol Lab

An Aging & Cancer Research Lab based at the University of Calgary

Arnie Charbonneau Cancer Institute

3280 Hospital Dr NW

Calgary, AB T2N 4Z6

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